Zinc pyrithione

Research use only, not for human use.

Zinc pyrithione is an antifungal and antibacterial agent disrupting membrane transport by blocking the proton pump.

Zinc pyrithione is an antifungal and antibacterial agent disrupting membrane transport by blocking the proton pump.(In Vitro):Zinc pyrithione is considered as a coordination complex of zinc. The pyrithione ligands, which are formally monoanions, are chelated to Zn 2+ via oxygen and sulfur centers. In the crystalline state, zinc pyrithione exists as a centrosymmetric dimer, where each zinc is bonded to two sulfur and three oxygen centers. In solution, however, the dimers dissociate via scission of one Zn-O bond. Zinc pyrithione, which is a dimer but is probably biologically active as a monomer, induces plasma membrane depolarization with half-maximal effect (K1/2) of about 0.3 mM.Zinc Pyrithione (10 nM-10 μM; 72 hours) significantly induces cell death in AAVS1 cells.

Zinc pyrithione is considered as a coordination complex of zinc. The pyrithione ligands, which are formally monoanions, are chelated to Zn 2+ via oxygen and sulfur centers. In the crystalline state, zinc pyrithione exists as a centrosymmetric dimer, where each zinc is bonded to two sulfur and three oxygen centers. In solution, however, the dimers dissociate via scission of one Zn-O bond. Zinc pyrithione, which is a dimer but is probably biologically active as a monomer, induces plasma membrane depolarization with half-maximal effect (K1/2) of about 0.3 mM. Zinc Pyrithione (10 nM-10 μM; 72 hours) significantly induces cell death in AAVS1 cells.

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AI3-62421, BC-J, Biocut ZP, Finecide ZPT, Pyrithione zinc | Zinc pyrithione

Membrane Transporter/Ion Channel

Proton Pump

Proton pump

Cardiovascular Disease

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13463-41-7

317.7

C10H8N2O2S2Zn

>98% (HPLC)

DMSO: 30 mg/mL (94.42 mM)

C1=CC2S=[Zn+2]3(S=C4C=CC=CN4[O-]3)[O-]N2C=C1

(T-4)-Bis(1-hydroxy-2(1H)-pyridinethionato-O,S)zinc

(-20℃)

With Ice Pack

≥ 2 years